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NALP6 Polyclonal Antibody
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Product Details
BS-10440R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human NALP6, amino acids 351-450.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP6, also known as PYPAF5, is highly expressed in granulocytes and T cells and co-localizes with the PYRIN-CARD protein ASC. Co-expression of NALP6 with ASC results in a synergistic activation of NF-kappa-B and activated caspase-1-dependent cytokine processing, suggesting that NALP6 functions in immune cells to coordinate the transduction of pro-inflammatory signals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Angiotensin II/vasopressin receptor; angiotensin/vasopressin receptor; dual angiotensin II/vasopressin receptor; NACHT, leucine rich repeat and PYD containing 6; NACHT, LRR and PYD domains-containing protein 6; NACHT/LRR/pyrin domain-containing protein 6; Non-angiotensin-vasopressin receptor; Non-AVR; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 6; PYPAF5; PYRIN-containing APAF1-like protein 5; PYRIN-containing APAF1-like protein 5-like; unnamed protein product
Gene Aliases: AI504961; AVR; CLR11.4; NALP6; NAVR; NAVR/AVR; NLRP6; PAN3; PYPAF5
UniProt ID: (Human) P59044, (Mouse) Q91WS2, (Rat) Q63035
Entrez Gene ID: (Human) 171389, (Mouse) 101613, (Rat) 171390
immune system process
acute inflammatory response to antigenic stimulus
acute inflammatory response
negative regulation of inflammatory response to antigenic stimulus
inflammatory response
signal transduction
G-protein coupled receptor signaling pathway
protein secretion
response to bacterium
regulation of autophagy
negative regulation of interferon-gamma production
positive regulation of interleukin-1 beta production
positive regulation of interleukin-18 production
negative regulation of toll-like receptor signaling pathway
interleukin-18-mediated signaling pathway
wound healing
negative regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of MAPK cascade
innate immune response
host-mediated regulation of intestinal microbiota composition
regulation of inflammatory response
positive regulation of inflammatory response
negative regulation of immune response
defense response to Gram-positive bacterium
protein homooligomerization
protein maturation
defense response to virus
regulation of mucus secretion
necroptotic process
pyroptosis
negative regulation of ERK1 and ERK2 cascade
interleukin-1-mediated signaling pathway
neutrophil mediated killing of gram-positive bacterium
antiviral innate immune response
NLRP6 inflammasome complex assembly
positive regulation of interleukin-18-mediated signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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