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NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP6, also known as PYPAF5, is highly expressed in granulocytes and T cells and co-localizes with the PYRIN-CARD protein ASC. Co-expression of NALP6 with ASC results in a synergistic activation of NF-kappa-B and activated caspase-1-dependent cytokine processing, suggesting that NALP6 functions in immune cells to coordinate the transduction of pro-inflammatory signals.
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Protein Aliases: Angiotensin II/vasopressin receptor; angiotensin/vasopressin receptor; dual angiotensin II/vasopressin receptor; NACHT, leucine rich repeat and PYD containing 6; NACHT, LRR and PYD domains-containing protein 6; NACHT/LRR/pyrin domain-containing protein 6; NLR family, pyrin domain containing 6; Non-angiotensin-vasopressin receptor; Non-AVR; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 6; PYRIN-containing APAF1-like protein 5; PYRIN-containing APAF1-like protein 5-like
Gene Aliases: AI504961; AVR; CLR11.4; NALP6; NAVR; NAVR/AVR; NLRP6; PAN3; PYPAF5
UniProt ID: (Human) P59044, (Mouse) Q91WS2, (Rat) Q63035
Entrez Gene ID: (Human) 171389, (Mouse) 101613, (Rat) 171390
Molecular Function:
nucleic acid binding
transcription cofactor
transcription factor
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