|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (106 GDAEEDSELAKPGEKEG 122) of NALP7 protein.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS with 0.05% BSA|
|Contains||0.05% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||5 µg/ml|
|Western Blot (WB)||0.25-1 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
NALP7 is a 980 amino acid containing short NALP belonging to the NLRP family with a DAPIN domain, nine LRR (leucine-rich) repeats and a NACHT domain. NALP7 is usually induced by LPS and IL-1B in peripheral blood mononuclear cells. A PYRIN-containing APAF-1-like protein, NALP7 directly interacts with CASP1 and IL-1B and acts as a feedback regulator of CASP1/caspase-1-dependent interleukin-1 beta secretion. It may play a crucial role in cell proliferation. Expressed in numerous tissues including uterus and ovary, with low levels in heart and brain but not detected in skeletal muscle. Defects in NLRP7 are the cause of hydatidiform mole (HYDM), an abnormal human pregnancy with no embryo and cystic degeneration of placental villi.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.