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PA1-1045 detects Visfatin (PBEF) in human samples.
PA1-1045 has been successfully used in Western blot procedures. In Western blot analysis of human adipose tissue lysate this antibody detects a ~52 kDa protein representing Visfatin.
The PA1-1045 immunogen is a synthetic peptide corresponding to residues S (472) F D E I R K N A Q L N I E L E A A H H (491) of human Visfatin.
Visfatin, also known as pre-B cell colony-enhancing factor, is an adipocytokine that is abundantly secreted by visceral adipose tissue, with insulin mimetic effects. Visfatin mimics insulin signaling by binding to the insulin receptor and reducing glucose release from liver cells, while stimulating glucose utilization in adipocytes and myocytes. Visfatin is also invoved in enhancement of cell proliferation, biosynthesis of nicotinamide mono-and dinucleotide and glucose homeostasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DKFZp666B131; EC 22.214.171.124; MGC117256; NAmPRTase; Nicotinamide phosphoribosyltransferase; Pre-B cell-enhancing factor; pre-B-cell colony enhancing factor 1; Pre-B-cell colony-enhancing factor 1; Visfatin
Gene Aliases: 1110035O14Rik; NAMPT; PBEF; PBEF1; VF; VISFATIN
UniProt ID: (Human) P43490
Entrez Gene ID: (Human) 10135
Molecular Function: transferase