Immunogen sequence: MKYQHVDPEE AVRIHTDVQT KKSMAIHWGT FALANEHYLE PPVKLNEALE RYGLNAEDFF VLKHGESRYL NNDDE
Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 85%.
N-Acylphosphatidylethanolamine (NAPE)-hydrolyzing phospholipase D (NAPE-PLD) is a membrane-bound enzyme which releases the endocannabinoid anandamide and other bioactive N-acylethanolamines from their corresponding NAPEs in animal tissues. NAPE-PLD has been shown to be expressed by specific populations of neurons in the brain and targeted to axonal processes. Recent studies have suggested that NAEs generated by NAPE-PLD in axons may act as anterograde synaptic signaling molecules that regulate the activity of postsynaptic neurons. NAPE-PLD has also been shown to catalyze the hydrolysis of NAPE to generate OEA (oleoylethanolamide), a natural lipid amide that inhibits food intake in free-feeding rodents by prolonging latency to feed and postmeal interval.
Protein Aliases: DKFZp781D1098; N-acyl phosphatidylethanolamine phospholipase D; N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D; NAPE-hydrolyzing phospholipase D
Gene Aliases: C7orf18; FMP30; NAPE-PLD; NAPEPLD
UniProt ID: (Human) Q6IQ20
Entrez Gene ID: (Human) 222236
Molecular Function: phospholipase