PA5-31880 targets NAPRT1 in IF, IHC (P), and WB applications and shows reactivity with Human samples.
The PA5-31880 immunogen is recombinant protein fragment corresponding to a region within amino acids 107 and 408 of Human NAPRT1.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
Nicotinic acid (NA; niacin) is converted by nicotinic acid phosphoribosyltransferase (NAPRT; EC 184.108.40.206) to NA mononucleotide (NaMN), which is then converted to NA adenine dinucleotide (NaAD), and finally to nicotinamide adenine dinucleotide (NAD), which serves as a coenzyme in cellular redox reactions and is an essential component of a variety of processes in cellular metabolism including response to stress (Hara et al., 2007).
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Protein Aliases: FHA-HIT-interacting protein; NAPRTase; Nicotinate phosphoribosyltransferase; nicotinate phosphoribosyltransferase domain containing 1; Nicotinate phosphoribosyltransferase domain-containing protein 1; nicotinic acid phosphoribosyltransferase; PP3856
Gene Aliases: FHIP; NAPRT; NAPRT1; PP3856
UniProt ID: (Human) Q6XQN6
Entrez Gene ID: (Human) 93100