This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: GTKFAIQYGT GRVDGILSED KLTIGGIKGA SVIFGEALWE PSLVF
Highest antigen sequence identity to the following orthologs: Mouse - 80%, Rat - 82%.
Napsin 1 is an aspartic protease that is generally expressed in the lung, but also present in kidney and in metastatic carcinomas throughout the body. Napsin 1 processes surfactant protein B in healthy pulmonary and renal tissues, but is abnormally regulated when carcinogenesis occurs. Thus, many researchers have found napsin evaluation to be useful in identifying several cancers, and differentiating primary tumors from metastases. When combined with thyroid transcription factor analysis, napsin can be used as a specific biomarker for differentiation of carcinoma types. Napsin has also been associated with pulmonary alveolar proteinosis as well as in protein catabolism in renal tubules.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: asp 4; ASP4; Aspartyl protease 4; kidney-derived aspartic protease-like protein; Napsin-1; Napsin-A; pronapsin A; TA01/TA02
Gene Aliases: KAP; Kdap; NAP1; NAPA; NAPSA; SNAPA
UniProt ID: (Human) O96009
Entrez Gene ID: (Human) 9476