IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation.
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Protein Aliases: 18S rRNA cytosine acetyltransferase; hALP; N-acetyltransferase 10; N-acetyltransferase 10 (GCN5-related); N-acetyltransferase-like protein; novel putative ATPase domain containing protein; RNA cytidine acetyltransferase
Gene Aliases: AI429152; ALP; KIAA1709; NAT10; NET43; RGD1306717