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Invitrogen
NBL1 Polyclonal Antibody
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Product Details
PA5-101110
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human NBL1(Accession P41271), corresponding to amino acid residues P142-D181.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total NBL1.
Target Information
This gene product is the founding member of the evolutionarily conserved CAN family of proteins, which contain a domain resembling the CTCK motif found in a number of signaling molecules. These proteins are secreted, and act as BMP antagonists by binding to BMPs and preventing them from interacting with their receptors. They may thus play an important role during growth and development. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DAN domain family member 1; differential screening-selected gene aberrant in neuroblastoma; N03; neuroblastoma candidate region, suppression of tumorigenicity 1; Neuroblastoma suppressor of tumorigenicity 1; Neuroblastoma, suppression of tumorigenicity 1 (DNA segment human D1S1733E); Protein N03; Zinc finger protein DAN
Gene Aliases: D1S1733E; DAN; DAND1; NB; NBL1; NO3
UniProt ID: (Human) P41271, (Rat) Q06880
Entrez Gene ID: (Human) 4681, (Rat) 50594
nervous system development
negative regulation of BMP signaling pathway
sequestering of BMP in extracellular matrix
sequestering of BMP from receptor via BMP binding
positive regulation of neuron differentiation
determination of dorsal identity
neuron projection morphogenesis
negative regulation of monocyte chemotaxis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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