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Invitrogen
NBS1 Polyclonal Antibody
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Product Details
PA5-22975
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide made to an internal portion of the mouse NBS1 protein (within residues 150-200).
Conjugate
Form
Liquid
Concentration
1.48 mg/mL
Amount
148 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 30% glycerol
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Suggested positive control: antigen standard for NBN (transient overexpression lysate), HeLa whole cell extract.
Target Information
The p95 gene (identical to NBS1 and nibrin) is a member of the hMre11/hRad50 double-strand break complex. This protein complex has been implicated in Nijmegen breakage syndrome, an autosomal recessive disorder marked by increased cancer incidence, cell cycle checkpoint deficits, and ionizing radiation sensitivity, thus revealing a direct molecular link between double-strand break repair and cell cycle checkpoint functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AT V1; AT V2; Cell cycle regulatory protein p95; FLJ10155; hNbs1; MGC87362; mutated in Nijmegen Breakage syndrome; Nibrin; Nijmegen breakage syndrome 1 (nibrin); Nijmegen breakage syndrome protein 1; Nijmegen breakage syndrome protein 1 homolog; OTTHUMP00000204088; p95 protein of the MRE11/RAD50 complex; p95-NBS1; unnamed protein product
Gene Aliases: AT-V1; AT-V2; ATV; hNbs1; NBN; NBS; NBS1; P95
UniProt ID: (Human) O60934, (Mouse) Q9R207
Entrez Gene ID: (Human) 4683, (Mouse) 27354
damaged DNA binding
protein binding
histone binding
protein serine/threonine kinase activator activity
phosphorylation-dependent protein binding
DNA-binding transcription factor binding
chromatin-protein adaptor activity
ATP-dependent DNA helicase activity
transcription factor binding
protein N-terminus binding
damaged DNA-binding protein
DNA damage checkpoint
telomere maintenance
double-strand break repair via homologous recombination
DNA double-strand break processing
in utero embryonic development
blastocyst growth
DNA repair
double-strand break repair
cellular response to DNA damage stimulus
mitotic G2 DNA damage checkpoint
neuroblast proliferation
regulation of DNA-dependent DNA replication initiation
DNA damage response, signal transduction by p53 class mediator
protection from non-homologous end joining at telomere
telomeric 3' overhang formation
positive regulation of telomere maintenance
reciprocal DNA recombination
telomere maintenance in response to DNA damage
mitotic G2/M transition checkpoint
isotype switching
neuromuscular process controlling balance
meiotic cell cycle
regulation of cell cycle
R-loop processing
protein K63-linked ubiquitination
t-circle formation
telomere maintenance via telomere trimming
intrinsic apoptotic signaling pathway
double-strand break repair via alternative nonhomologous end joining
DNA strand resection involved in replication fork processing
negative regulation of telomere capping
positive regulation of double-strand break repair via homologous recombination
protein localization to site of double-strand break
positive regulation of double-strand break repair
cell cycle
mitotic cell cycle checkpoint
cell proliferation
positive regulation of cell proliferation
positive regulation of protein autophosphorylation
DNA duplex unwinding
positive regulation of kinase activity
negative regulation of neuron differentiation
negative regulation of viral entry into host cell
regulation of fibroblast proliferation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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