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Invitrogen
NBS1 Polyclonal Antibody
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FIGURE: 1 / 5
NBS1 Antibody (PA5-78071) in ICC/IF
NBS1 Polyclonal Antibody detects NBS1 protein at nucleus by immunofluorescent analysis. Sample: A431 cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: NBS1 stained by NBS1 Polyclonal Antibody (Product # PA5-78071) diluted at 1:500. Red: phalloidin, a cytoskeleton marker, diluted at 1:200.
Product Details
PA5-78071
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human NBS1. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Control: 293T, NT2D1
Predicted Reactivity: Rhesus Monkey (94%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The p95 gene (identical to NBS1 and nibrin) is a member of the hMre11/hRad50 double-strand break complex. This protein complex has been implicated in Nijmegen breakage syndrome, an autosomal recessive disorder marked by increased cancer incidence, cell cycle checkpoint deficits, and ionizing radiation sensitivity, thus revealing a direct molecular link between double-strand break repair and cell cycle checkpoint functions.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AT V1; AT V2; Cell cycle regulatory protein p95; FLJ10155; hNbs1; MGC87362; mutated in Nijmegen Breakage syndrome; Nibrin; Nijmegen breakage syndrome 1 (nibrin); Nijmegen breakage syndrome protein 1; OTTHUMP00000204088; p95 protein of the MRE11/RAD50 complex; p95-NBS1; unnamed protein product
Gene Aliases: AT-V1; AT-V2; ATV; hNbs1; NBN; NBS; NBS1; P95
UniProt ID: (Human) O60934
Entrez Gene ID: (Human) 4683
DNA damage checkpoint
telomere maintenance
double-strand break repair via homologous recombination
DNA double-strand break processing
in utero embryonic development
blastocyst growth
DNA repair
double-strand break repair
cellular response to DNA damage stimulus
mitotic G2 DNA damage checkpoint
neuroblast proliferation
regulation of DNA-dependent DNA replication initiation
DNA damage response, signal transduction by p53 class mediator
protection from non-homologous end joining at telomere
telomeric 3' overhang formation
positive regulation of telomere maintenance
reciprocal DNA recombination
telomere maintenance in response to DNA damage
mitotic G2/M transition checkpoint
isotype switching
neuromuscular process controlling balance
meiotic cell cycle
regulation of cell cycle
R-loop processing
protein K63-linked ubiquitination
t-circle formation
telomere maintenance via telomere trimming
intrinsic apoptotic signaling pathway
double-strand break repair via alternative nonhomologous end joining
DNA strand resection involved in replication fork processing
negative regulation of telomere capping
positive regulation of double-strand break repair via homologous recombination
protein localization to site of double-strand break
positive regulation of double-strand break repair
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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