Peptide sequence: KAIIDEFEQK LRACHTRGLD GIKELEIGQA GSQRAPSAKK PSTGSRYQPL
Sequence homology: Dog: 79%; Horse: 93%; Human: 100%; Pig: 92%; Rabbit: 92%
NCAPD2 is the regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. NCAPD2 may target the condensin complex to DNA via its C-terminal domain.
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Protein Aliases: CAP-D2; chromosome condensation related SMC associated protein 1; Chromosome condensation-related SMC-associated protein 1; Chromosome-associated protein D2; CNAP1; Condensin complex subunit 1; hCAP-D2; KIAA0159; Non-SMC condensin I complex; Non-SMC condensin I complex subunit D2; non-SMC condensin I complex, subunit D2; subunit D2; XCAP-D2 homolog
Gene Aliases: CAP-D2; CAPD2; CNAP1; hCAP-D2; KIAA0159; NCAPD2
UniProt ID: (Human) Q15021
Molecular Function: nucleic acid binding