Immunogen sequence: RKNSARKASI VKNLKDTLGI GKVKRKPSVP DSASPADDSF VDPGERLYDL NMPAYVKFNY MAEREDELSL IKGTKVIVME KCSDGWWRGS YNGQVGWFPS NYVTEEGDSP LGDHVGSLSE KLAAVVNNLN TGQVLHVVQA LYPFSSSNDE ELNFEKGDVM DVIEKPENDP EWWKCRKING MVGLVPKNYV TVMQNNPLTS GLEPSPPQCD YIRPSLTGKF AGNPWYYGKV TRHQAEMALN ERGHEGDFLI RDSESSPNDF SVSLKAQGKN KHFKVQLKET VYCIGQRKFS TMEELVEHYK KAPIFTSEQG EKLYLVKHLS; Positive Samples: Mouse brain; Cellular Location: Cytoplasm, Endoplasmic reticulum, Nucleus
NCK1 is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found.
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Protein Aliases: Cytoplasmic protein NCK1; melanoma NCK protein; NCK adaptor protein 1; NCK tyrosine kinase; Nck-1; non-catalytic region of tyrosine kinase; non-catalytic region of tyrosine kinase adaptor protein 1; SH2/SH3 adaptor protein NCK-alpha
Gene Aliases: 6330586M15Rik; D230010O13Rik; NCK; Nck-1; NCK1; NCKalpha