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Invitrogen
NCKAP1L Polyclonal Antibody
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Product Details
PA5-59292
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human NCKAP1L. Recombinant protein control fragment (Product #RP-97720).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: FRAMAQEGLR EVFSSHCPFL MGPIECLKEF VTPDTDIKVT LSIFELASAA GVGCDIDPAL VAAIANLKAD TSSPEE
Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 92%.
Target Information
This gene encodes a member of the HEM family of tissue-specific transmembrane proteins which are highly conserved from invertebrates through mammals. This gene is only expressed in hematopoietic cells. The encoded protein is a part of the Scar/WAVE complex which plays an important role in regulating cell shape in both metazoans and plants. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Hematopoietic protein 1; Membrane-associated protein HEM-1; Nck-associated protein 1-like; unnamed protein product
Gene Aliases: HEM1; IMD72; NCKAP1L
UniProt ID: (Human) P55160
Entrez Gene ID: (Human) 3071
cell morphogenesis
B cell homeostasis
myeloid cell homeostasis
positive regulation of leukocyte migration
chemotaxis
response to xenobiotic stimulus
cell migration
maintenance of cell polarity
cell projection assembly
positive regulation of actin filament polymerization
cortical actin cytoskeleton organization
positive regulation of B cell proliferation
negative regulation of interleukin-17 production
negative regulation of interleukin-6 production
positive regulation of cell adhesion mediated by integrin
erythrocyte homeostasis
intracellular signal transduction
positive regulation of T cell proliferation
T cell homeostasis
negative regulation of apoptotic process
negative regulation of cytotoxic T cell degranulation
positive regulation of CD4-positive, alpha-beta T cell differentiation
positive regulation of CD8-positive, alpha-beta T cell differentiation
positive regulation of B cell differentiation
positive regulation of gamma-delta T cell differentiation
positive regulation of lymphocyte differentiation
positive regulation of erythrocyte differentiation
neuron projection morphogenesis
erythrocyte development
B cell receptor signaling pathway
positive regulation of phagocytosis, engulfment
protein-containing complex assembly
actin polymerization-dependent cell motility
positive regulation of neutrophil chemotaxis
positive regulation of neutrophil migration
positive regulation of TORC2 signaling
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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