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Product Details
PA5-59292
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human NCKAP1L. Recombinant protein control fragment (Product #RP-97720).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2644517
Product Specific Information
Immunogen sequence: FRAMAQEGLR EVFSSHCPFL MGPIECLKEF VTPDTDIKVT LSIFELASAA GVGCDIDPAL VAAIANLKAD TSSPEE^M
^M
Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 92%.
Target Information
This gene encodes a member of the HEM family of tissue-specific transmembrane proteins which are highly conserved from invertebrates through mammals. This gene is only expressed in hematopoietic cells. The encoded protein is a part of the Scar/WAVE complex which plays an important role in regulating cell shape in both metazoans and plants. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Hematopoietic protein 1; Membrane-associated protein HEM-1; Nck-associated protein 1-like
Gene Aliases: HEM1; NCKAP1L
UniProt ID: (Human) P55160
Entrez Gene ID: (Human) 3071
B cell homeostasis
myeloid cell homeostasis
protein complex assembly
chemotaxis
maintenance of cell polarity
neutrophil chemotaxis
positive regulation of actin filament polymerization
cortical actin cytoskeleton organization
positive regulation of B cell proliferation
activation of protein kinase activity
negative regulation of interleukin-17 production
negative regulation of interleukin-6 production
positive regulation of cell adhesion mediated by integrin
negative regulation of myosin-light-chain-phosphatase activity
Fc-gamma receptor signaling pathway involved in phagocytosis
positive regulation of T cell proliferation
positive regulation of phosphorylation
response to drug
T cell homeostasis
negative regulation of apoptotic process
positive regulation of CD4-positive, alpha-beta T cell differentiation
positive regulation of CD8-positive, alpha-beta T cell differentiation
positive regulation of GTPase activity
positive regulation of B cell differentiation
positive regulation of gamma-delta T cell differentiation
positive regulation of lymphocyte differentiation
positive regulation of erythrocyte differentiation
vascular endothelial growth factor receptor signaling pathway
erythrocyte development
B cell receptor signaling pathway
positive regulation of phagocytosis, engulfment
actin polymerization-dependent cell motility
positive regulation of neutrophil chemotaxis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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