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|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||An 18 amino acid synthetic peptide near the carboxy terminus of human NCLN|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Immunocytochemistry (ICC)||20 ug/ml|
|Immunofluorescence (IF)||2.5 ug/mL|
|Immunohistochemistry (IHC)||2.5 ug/mL|
|Western Blot (WB)||0.5 ug/mL|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
A suggested positive control is mouse heart tissue lysate.
PA5-34356 can be used with blocking peptide PEP-1399.
Nicalin, along with its binding partner Nomo, is a novel signaling antagonist to Nodals, signaling factors of the TGF-Beta superfamily that play a key role in vertebrate development. Nicalin is distantly related to Nicastrin, a component of the Alzheimer's disease-associated gamma-secretase, and is thought to have a similar function. Another protein, TMEM147, has also been recently identified as associating with Nicalin and NOMO as part of the gamma-secretase-like complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
NCLN; NET59; nicalin; nicalin homolog; nicastrin-like protein
3100002P13Rik; AW120537; NCLN; NET59; RGD1309355