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This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.
Protein Aliases: h KIAA1047; hCIT529I10; MGC104216; N-CoR; N-CoR1; nuclear receptor corepressor; Nuclear receptor corepressor 1; protein phosphatase 1, regulatory subunit 109; retinoid X receptor interacting protein 13; retinoid X receptor-interacting protein 13; thyroid hormone- and retinoic acid receptor-associated corepressor 1
Gene Aliases: 5730405M06Rik; A230020K14Rik; hN-CoR; KIAA1047; mKIAA1047; N-CoR; N-CoR1; NCOR1; PPP1R109; RIP13; Rxrip13; TRAC1
UniProt ID: (Human) O75376
Molecular Function: chromatin/chromatin-binding, or -regulatory protein