FIGURE: 1 / 3
Keep as concentrated solution.
Predicted reactivity: Bovine (100%).
Positive Control: HeLa WCE and NE.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: h KIAA1047; hCIT529I10; MGC104216; N-CoR; nuclear receptor corepressor; Nuclear receptor corepressor 1; protein phosphatase 1, regulatory subunit 109; thyroid hormone- and retinoic acid receptor-associated corepressor 1
Gene Aliases: hN-CoR; KIAA1047; N-CoR; N-CoR1; NCOR1; PPP1R109; TRAC1
UniProt ID: (Human) O75376
Entrez Gene ID: (Human) 9611
Molecular Function: chromatin/chromatin-binding, or -regulatory protein