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Immunogen sequence: PNRLESLRK LKASLQGDVQ KYQAYMSNLE SHSAILDQKL NGLNEEIARV ELECETIKQE NTRLQNIIDN QKYSVADIER INHERNELQQ TINKLTKDLE AEQQKLWNEE LKYARGKEAI ETQLAEYHKL ARKLKLIPKG AENSKGYDFE IKFNPEAGAN CLVKYRAQVY VPLKELLNET EEEINKALNK KMGLEDTLEQ LNAMITESKR SVRTLKEEVQ KLDDLYQQKI KEAEEEDEKC ASELESLEKH KHLLESTVNQ GLSEAMNELD AVQREYQLVV QTTTEERRKV GNNLQRLLEM VATHVGSVEK HLEEQIAKVD REYEECMSED LSENIKEIRD KYEKKATLIK SSEE (290-642 aa encoded by B C035617)
Hec1 is one of several proteins involved in spindle checkpoint signaling. This surveillance mechanism assures correct segregation of chromosomes during cell division by detecting unaligned chromosomes and causing prometaphase arrest until the proper bipolar attachment of chromosomes is achieved.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: HEC-1; HEC2; HEC4; Highly expressed in cancer protein; highly expressed in cancer, rich in leucine heptad repeats; HsHec1; kinetochore associated 2; Kinetochore protein Hec1; Kinetochore protein NDC80 homolog; Kinetochore-associated protein 2; NDC80 homolog, kinetochore complex component; NDC80 kinetochore complex component homolog; Retinoblastoma-associated protein HEC
Gene Aliases: 2610020P18Rik; AV139730; HEC; HEC1; HsHec1; hsNDC80; KNTC2; NDC80; TID3
Molecular Function: transcription cofactor