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Invitrogen
NDFIP1 Polyclonal Antibody
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FIGURE: 1 / 7
NDFIP1 Antibody (PA5-101992) in IHC (P)
Immunohistochemistry analysis of NDFIP1 in mouse colorectal tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with NDFIP1 polyclonal antibody (Product # PA5-101992) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-101992
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human NDFIP1(Accession Q9BT67), corresponding to amino acid residues Y178-Y221.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total NDFIP1.
Target Information
The NEDD4 family-interacting protein 1 (NDFIP1) belongs to a small group of evolutionarily conserved proteins with three transmembrane domains and is an integral Golgi membrane protein. It is a potential target for ubiquitination by the Nedd4 family of proteins. NDFIP1 is strongly expressed in surviving neurons following acute cortical brain injury, and overexpression in cultured cortical neurons increased survival following growth factor starvation, suggesting that NDFIP1 may play a role in neuronal survival. NDFIP1 and the related protein NDFIP2 are thought to interact with and regulate multiple components of the EGF and PTEN/Akt signaling pathways. Recent studies suggest that NDFIP1 may also play a role in Th17 differentiation by limiting the production of proinflammatory cytokines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Breast cancer-associated protein SGA-1M; NEDD4 family-interacting protein 1; Nedd4 WW binding protein 5; NEDD4 WW domain-binding protein 5; Nedd4 WW-binding protein 5; Putative MAPK-activating protein PM13; Putative NF-kappa-B-activating protein 164; Putative NFKB and MAPK-activating protein
Gene Aliases: 0610010M22Rik; N4WBP5; NDFIP1; PSEC0192; PSEC0223
UniProt ID: (Human) Q9BT67, (Rat) Q5U2S1, (Mouse) Q8R0W6
Entrez Gene ID: (Human) 80762, (Rat) 291609, (Mouse) 65113
regulation of myeloid leukocyte differentiation
negative regulation of type 2 immune response
cellular iron ion homeostasis
vacuolar transport
signal transduction
negative regulation of gene expression
metal ion transport
positive regulation of protein ubiquitination
negative regulation of transporter activity
negative regulation of interleukin-4 production
negative regulation of T cell proliferation
positive regulation of I-kappaB kinase/NF-kappaB signaling
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
regulation of lymphocyte differentiation
positive regulation of protein catabolic process
negative regulation of isotype switching to IgE isotypes
regulation of isotype switching to IgG isotypes
negative regulation of inflammatory response
negative regulation of protein transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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