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Invitrogen
NDNL2 Polyclonal Antibody
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Product Details
PA5-50619
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues near the C terminal of human necdin-like 2
Conjugate
Form
Liquid
Concentration
2.9 mg/mL
Amount
290 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody detects endogenous levels of total HCA-4 protein.
Target Information
The protein encoded by this gene is part of the SMC5-6 chromatin reorganizing complex and is a member of the MAGE superfamily. This is an intronless gene. Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Hepatocellular carcinoma-associated protein 4; hepatocellular carcinoma-associated protein HCA4; MAGE-G1 antigen; magg1; melanoma antigen, family G, 1; Melanoma-associated antigen G1; necdin-like 2, SMC5-SMC6 complex component; necdin-like gene 2; Necdin-like protein 2; Non-SMC element 3 homolog; Non-structural maintenance of chromosomes element 3 homolog; NSE3 homolog, SMC5-SMC6 complex component; unnamed protein product
Gene Aliases: 5730494G16Rik; AI642138; BB044375; HCA4; LICS; mage-g1; MAGEG1; MAGEL3; NDNL2; NSE3; NSMCE3
UniProt ID: (Human) Q96MG7, (Mouse) Q9CPR8
Entrez Gene ID: (Human) 56160, (Mouse) 66647
negative regulation of transcription from RNA polymerase II promoter
double-strand break repair via homologous recombination
DNA repair
DNA recombination
cellular response to DNA damage stimulus
protein sumoylation
positive regulation of protein ubiquitination
regulation of telomere maintenance
cellular response to UV
regulation of macromolecule metabolic process
cellular response to radiation
cellular response to hydroxyurea
regulation of primary metabolic process
chromatin looping
regulation of transcription, DNA-templated
regulation of growth
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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