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Proteintech
NDST1 Polyclonal Antibody
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Product Details
26203-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
NDST1 Fusion Protein Ag24422 (38-90 aa encoded by BC012888)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Amount
40.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: LYGWKRGLE PSADAPEPDC GDPPPVAPSR LLPLKPVQAA TPSRTDPLVL VFVE (38-90 aa encoded by BC012888)
Target Information
Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence is absolutely required. Participates in biosynthesis of heparan sulfate that can ultimately serve as L- selectin ligands, thereby playing a role in inflammatory response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: [Heparan sulfate]-glucosamine N-sulfotransferase 1; Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1; Glucosaminyl N-deacetylase/N-sulfotransferase 1; Golgi heparan sulfate N-deacetylase/N-sulfotransferase; heparan sulfate-N-deacetylase/N-sulfotransferase; heparan sulfate/heparin GlcNAc N-deacetylase/GlcN N-sulfotransferase 1; HSNST 1; N-Deacetylase-N-sulfotransferase 1; N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1; N-deacetylase/N-sulfotransferase 1; N-deacetylase/N-sulfotransferase-1; N-heparan sulfate sulfotransferase 1; N-HSST; N-HSST 1; NDST-1; unnamed protein product
Gene Aliases: 1200015G06Rik; b2b2230Clo; HSST; HSST1; MRT46; NDST-1; NDST1; NST1
UniProt ID: (Human) P52848, (Rat) Q02353, (Mouse) Q3UHN9
Entrez Gene ID: (Human) 3340, (Rat) 29633, (Mouse) 15531
catalytic activity
protein binding
sulfotransferase activity
[heparan sulfate]-glucosamine N-sulfotransferase activity
transferase activity
hydrolase activity
deacetylase activity
N-acetylglucosamine deacetylase activity
heparan sulfate N-deacetylase activity
N-acetylglucosamine 6-O-sulfotransferase activity
N-acetylgalactosamine 4-O-sulfotransferase activity
GPI-anchor transamidase activity
heparan sulfate 2-O-sulfotransferase activity
HNK-1 sulfotransferase activity
heparan sulfate 6-O-sulfotransferase activity
trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity
1-phenanthrol sulfotransferase activity
3-phenanthrol sulfotransferase activity
4-phenanthrol sulfotransferase activity
trans-3,4-dihydrodiolphenanthrene sulfotransferase activity
9-phenanthrol sulfotransferase activity
2-phenanthrol sulfotransferase activity
phenanthrol sulfotransferase activity
1-hydroxypyrene sulfotransferase activity
galactose 3-O-sulfotransferase activity
proteoglycan sulfotransferase activity
cholesterol sulfotransferase activity
coenzyme F390-A hydrolase activity
coenzyme F390-G hydrolase activity
hydroxyjasmonate sulfotransferase activity
transferase
polysaccharide biosynthetic process
cardiac septum development
inflammatory response
heart development
respiratory gaseous exchange
cell proliferation
fibroblast growth factor receptor signaling pathway
organ morphogenesis
heparan sulfate proteoglycan biosynthetic process
glycosaminoglycan metabolic process
heparin biosynthetic process
forebrain development
midbrain development
aorta development
positive regulation of MAPK cascade
positive regulation of smoothened signaling pathway
embryonic neurocranium morphogenesis
embryonic viscerocranium morphogenesis
coronary vasculature development
MAPK cascade
protein sulfation
smoothened signaling pathway
protein deacetylation
metabolic process
embryo development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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