Immunogen sequence: YEPVLLAKTR SSESIPHLGA DAGLHAALHA TVVQ
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence is absolutely required. Participates in biosynthesis of heparan sulfate that can ultimately serve as L- selectin ligands, thereby playing a role in inflammatory response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 282-; 3---; [Heparan sulfate]-glucosamine N-sulfotransferase 1; Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1; Glucosaminyl N-deacetylase/N-sulfotransferase 1; Heparan sulfate N-deacetylase 1; Heparan sulfate N-sulfotransferase 1; heparan sulfate-N-deacetylase/N-sulfotransferase; heparan sulfate/heparin GlcNAc N-deacetylase/GlcN N-sulfotransferase 1; HSNST 1; HSST; HSST1; N-Deacetylase-N-sulfotransferase 1; N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1; N-deacetylase/N-sulfotransferase 1; N-heparan sulfate sulfotransferase 1; N-HSST 1; NDST-1; NDST1
Gene Aliases: HSST; HSST1; MRT46; NDST1; NST1
UniProt ID: (Human) P52848
Entrez Gene ID: (Human) 3340