Applications | Tested Dilution | Publications |
---|---|---|
Western Blot (WB) |
1:500-1:5,000 | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:500-1:1,000 | - |
ELISA (ELISA) |
Assay-Dependent | - |
Product Specifications | |
---|---|
Species Reactivity |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Recombinant Human NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 protein (117-169AA) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
2.78 mg/mL |
Purification |
Protein G |
Storage buffer |
PBS, pH 7.4, with 50% glycerol |
Contains |
0.03% Proclin 300 |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_2813280 |
Mimitin, a small mitochondrial protein, whose transcription is directly stimulated by c-Myc, is highly expressed in 80% of esophageal squamous cell carcinomas (ESCC). Suppression of Mimitin expression by RNA interference had no effect in cancerous cell lines such as human cervical carcinoma or hepatocarcinoma cell lines, but caused a decrease in cell proliferation in human glioblastoma, embryonic lung fibroblastic cells, and ESCC, suggesting Mimitin may play a special role in these types of cells. Mimitin expression is also regulated by MAPK kinases and IL-1, but not through the NF-kappa-B-related pathway. It will interact with the microtubular protein MAP1S and can affect the activities of caspase-3 and -7 in cells stimulated to develop apoptosis. Other experiments suggest that Mimitin also acts as a molecular chaperone for the assembly of the mitochondrial complex I.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: B17.2-like; B17.2L; B172-like; B172L; Mimitin; MMTN; Myc-induced mitochondrial protein; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 2; NADH dehydrogenase (ubiquinone) complex I, assembly factor 2; NADH dehydrogenase 1 alpha subcomplex assembly factor 2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2; NDUFA12-like protein
Gene Aliases: B17.2L; mimitin; MMTN; NDUFA12L; NDUFAF2
UniProt ID: (Human) Q8N183
Entrez Gene ID: (Human) 91942
Molecular Function:
chaperone
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