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Invitrogen
This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: RSLRTSTWRL AQDQTQDTQL ITVDEKLDIT TLTGVPEEHI KTRKVRIFVP ARNNMQSGVN NTKKWKMEFD TRERWENPLM GWASTADPLS NMVLTFSTKE DAVSFAEKNG WSYDIEERKV PKPKSKSYGA NFSWNKRTRV S
Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 91%.
This gene encodes an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), or NADH:ubiquinone oxidoreductase, the first multi-subunit enzyme complex of the mitochondrial respiratory chain. Complex I plays a vital role in cellular ATP production, the primary source of energy for many crucial processes in living cells. It removes electrons from NADH and passes them by a series of different protein-coupled redox centers to the electron acceptor ubiquinone. In well-coupled mitochondria, the electron flux leads to ATP generation via the building of a proton gradient across the inner membrane. Complex I is composed of at least 41 subunits, of which 7 are encoded by the mitochondrial genome and the remainder by nuclear genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 18-KD; AQDQ; CI-18; CI-18 kDa; CI-AQDQ; complex I 18kDa subunit; Complex I-18 kDa; Complex I-AQDQ; mitochondrial; mitochondrial respiratory chain complex I (18-KD subunit); NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase); NADH dehydrogenase (ubiquinone) iron-sulfur protein 4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial; NADH-coenzyme Q reductase; NADH-ubiquinone oxidoreductase 18 kDa subunit
Gene Aliases: 6720411N02Rik; AQDQ; C1-18k; CI-18; CI-18 kDa; CI-AQDQ; NDUFS4
UniProt ID: (Human) O43181, (Mouse) Q9CXZ1, (Rat) Q5XIF3
Entrez Gene ID: (Human) 4724, (Mouse) 17993, (Rat) 499529
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