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Invitrogen
NDUFS4 Polyclonal Antibody
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Product Details
PA5-52010
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human NDUFS4. Recombinant protein control fragment (Product #RP-102243).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: RSLRTSTWRL AQDQTQDTQL ITVDEKLDIT TLTGVPEEHI KTRKVRIFVP ARNNMQSGVN NTKKWKMEFD TRERWENPLM GWASTADPLS NMVLTFSTKE DAVSFAEKNG WSYDIEERKV PKPKSKSYGA NFSWNKRTRV S
Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 91%.
Target Information
This gene encodes an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), or NADH:ubiquinone oxidoreductase, the first multi-subunit enzyme complex of the mitochondrial respiratory chain. Complex I plays a vital role in cellular ATP production, the primary source of energy for many crucial processes in living cells. It removes electrons from NADH and passes them by a series of different protein-coupled redox centers to the electron acceptor ubiquinone. In well-coupled mitochondria, the electron flux leads to ATP generation via the building of a proton gradient across the inner membrane. Complex I is composed of at least 41 subunits, of which 7 are encoded by the mitochondrial genome and the remainder by nuclear genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CI-18 kDa; CI-AQDQ; complex I 18kDa subunit; Complex I-18 kDa; Complex I-AQDQ; mitochondrial respiratory chain complex I (18-KD subunit); NADH dehydrogenase (ubiquinone) Fe-S protein 4 18kDa (NADH-coenzyme Q reductase) isoform NDUFS4_1; NADH dehydrogenase (ubiquinone) Fe-S protein 4 18kDa (NADH-coenzyme Q reductase) isoform NDUFS4_2; NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase); NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial; NADH-ubiquinone oxidoreductase 18 kDa subunit; subunit of Mitochondrial Complex I
Gene Aliases: 6720411N02Rik; AQDQ; C1-18k; CI-18; CI-18 kDa; CI-AQDQ; MC1DN1; NDUFS4
UniProt ID: (Human) O43181, (Mouse) Q9CXZ1, (Rat) Q5XIF3
Entrez Gene ID: (Human) 4724, (Mouse) 17993, (Rat) 499529
regulation of protein phosphorylation
mitochondrial electron transport, NADH to ubiquinone
brain development
aerobic respiration
electron transport chain
mitochondrial respiratory chain complex I assembly
mitochondrial ATP synthesis coupled proton transport
response to cAMP
reactive oxygen species metabolic process
hydrogen ion transmembrane transport
transport
cAMP-mediated signaling
cellular respiration
positive regulation of fibroblast proliferation
oxidation-reduction process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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