Immunogen sequence: CTELISDIRY KEEFKKSKDK CTFVTDSPML NHVKNIGAFI SEAKYKGTIK ADLSNSLYKR MPATIDSVFA GEVTQLQSEV AYKQKHDAAK GFSDYAHMKE PPEVKHAMEV NKHQSNISYR KDVQDTHTYS AELDRPD
Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 85%.
Nebulette encodes a nebulin like protein that is abundantly expressed in cardiac muscle. The encoded protein binds actin and interacts with thin filaments and Z-line associated proteins in striated muscle. This protein may be involved in cardiac myofibril assembly. A shorter isoform of this protein termed LIM nebulette is expressed in non-muscle cells and may function as a component of focal adhesion complexes. Alternate splicing results in multiple transcript variants.
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Protein Aliases: Actin-binding Z-disk protein; LIM and SH3 protein 2; LIM-nebulette; Nebulette
Gene Aliases: LASP2; LNEBL; NEBL
UniProt ID: (Human) O76041
Entrez Gene ID: (Human) 10529