Immunogen sequence: GSYSSNGSDF GSCASITSGG SYTNSVISDS SSYTFPPSDD TFLGGNLPSD STSNRSVPNR NTTPCEIFSR STSTDPFVQD DLEHGLEIMK LPVSRNTKIP LKRYSSLVIF PRSPSTTRPT SPTSLCTLLS KGSYQTSHQF IISPSEIAHN EDGTSAKGFL STAVNGLRLS KTICTPGEVR DIRPLHRKGS LQKKIVLSNN TPRQTVCEKS SEGYSCVSVH FTQRKAATLD CETTNGDCKP EMSEIKLNSD SEYIKLMHRT SACLPSSQNV DCQININGEL ERPHSQMNKN HGILRRSISL G; Positive Samples: U-251MG, HeLa, Jurkat, A-549, SKOV3; Cellular Location: Cell membrane, Cytoplasm, Peripheral membrane protein
The E3 ubiquitin-protein ligase NEDD4 is a Ubl conjugation pathway protein. It contains one HECT (E6AP-type E3 ubiquitin-protein ligase) domain and four WW domains. It is involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. It acts as a potential proto-oncogene that negatively regulates PTEN via ubiquitination, a paradigm analogous to that of Mdm2 and p53. It is also reported to be involved in the budding of many viruses and is the regulator of epithelial Na+ channels, which lead to arterial hypertension. NEDD4 protein is localized to the sarcolemmal region of muscle fibers. Increase in NEDD4 protein expression leads to unloaded and denervated muscles as well as a decrease in Notch1 expression. Hence it acts as down regulator of Notch-1 gene expression.
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Protein Aliases: Cell proliferation-inducing gene 53 protein; E3 ubiquitin-protein ligase NEDD4; HECT-type E3 ubiquitin transferase NEDD4; NEDD-4; Neural precursor cell expressed developmentally down-regulated protein 4; receptor-potentiating factor 1
Gene Aliases: KIAA0093; NEDD4; NEDD4-1; PIG53; RPF1
UniProt ID: (Human) P46934
Entrez Gene ID: (Human) 4734