NEDD4L is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. NEDD4L inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. NEDD4L promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. NEDD4L also promotes ubiquitination and degradation of SGK.
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Protein Aliases: E3 ubiquitin-protein ligase NEDD4-like; HECT-type E3 ubiquitin transferase NED4L; Nedd4-2; NEDD4.2; ubiquitin-protein ligase Rsp5
Gene Aliases: hNEDD4-2; KIAA0439; NEDD4-2; NEDD4.2; NEDD4L; NEDL3; RSP5
UniProt ID: (Human) Q96PU5
Entrez Gene ID: (Human) 23327