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Bioss
NEEP21 Polyclonal Antibody
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Product Details
BS-8204R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human NEEP21, amino acids 1-100.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
NEEP21 (neuron-enriched endosomal 21kDa protein), also known as brain neuron cytoplasmic protein 1, NSG1 (neuron-specific proteins family member 1), P21 or D4S234E, is a single pass type II membrane protein belonging to the NSG family. It is highly expressed during neuronal maturation but its expression is downregulated in adult tissues. NEEP21 predominantly localizes to Rab 4-positive early endosomes in the somatodendritic neuronal compartment and is essential for proper receptor sorting and recycling in neurons. It associates with GRIP1 and GluR-2 and mediates the surface expression of GluR-2. When this interaction is interrupted, GluR-2 accumulates in early endosomes and leads to changes in evoked synaptic current properties. In addition, NEEP21 forms a complex with the SNARE protein, Syntaxin 13 (also known as Syntaxin 12), and participates in the recycling of transferrin receptors (TFRs) and NTR2 (Neurotensin receptor 2).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: brain neuron cytoplasmic protein 1; Brain neuron cytoplasmic protein 1/2; brain specific mRNA b; carboxyterminally EE-tagged neuron-enriched endosomal 21 kDa protein; M234; Neuron-enriched endosomal protein of 21 kDa; Neuron-specific protein family member 1; Neuronal vesicle trafficking-associated protein 1; p21
Gene Aliases: Bsmrb; D4S234; D4S234E; m234; NEEP21; NSG1; P21; PEP1
UniProt ID: (Human) P42857, (Mouse) Q62092, (Rat) P02683
Entrez Gene ID: (Human) 27065, (Mouse) 18196, (Rat) 25247
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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