Immunogen sequence: LSFTSVGSIT SGYSQSSQVF LDLAQQNLYR DVMLENYRNL FSVGLTVCKP GLITCLEQRK EPWNVKRQEA ADGHPEMGFH HATQACLELL GSSDLPASAS QSAGITGVNH RAQPGLNVSV DKFTAMSSHF TQDLLPEQGI QDAFPKRILR GYGNCGLDNL YLRKDWESLD ECKLQKDYNG LNQCSSTTHS KIFQYNKYVK IFDNFSNLHR RNISNTGEKP FKCQECGKSF QMLSFLTEHQ KIHTGKKFQK; Positive Samples: MCF7
Involved in the maintenance of neuronal caliber, neurofilaments are the intermediate filament proteins found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H. Like most other intermediate filament proteins (IFPs), the expression of the different neuronal IFPs is both tissue-specific and developmentally regulated. NF-L is the light or low molecular weight microfilament subunit and runs on SDS-PAGE gels at approximately 70 kDa. Neurofilament are the 10nm or intermediate filament proteins found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H. NF-H is the heavy or high molecular weight microfilament subunit and runs on SDS-PAGE gels in the range 180-220 kDa, with some variation in different species.
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Protein Aliases: 68 kDa neurofilament protein; light molecular weight neurofilament protein; Neurofilament light polypeptide; neurofilament protein L; neurofilament protein, light chain; neurofilament subunit NF-L; Neurofilament triplet L protein; neurofilament, light polypeptide 68kDa; NF-L; protein phosphatase 1, regulatory subunit 110
Gene Aliases: AI847934; CMT1F; CMT2E; NEFL; NF-L; NF68; NFL; PPP1R110