Immunogen sequence: IHPLSLGSVL SASRREVLVD HVVEFSTAWL QGKFQGRPQH TQVYQKEQCP AGHQVMKEAF GPEDGLQRLT WWCPQCQPQL SEEPEQCQFS
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DNA glycosylase/AP lyase Neil2; DNA-(apurinic or apyrimidinic site) lyase Neil2; Endonuclease 8-like 2; Endonuclease VIII-like 2; NEH2; nei endonuclease VIII-like 2; Nei homolog 2; nei like 2; nei-like DNA glycosylase 2; Nei-like protein 2
Gene Aliases: NEH2; NEI2; NEIL2
UniProt ID: (Human) Q969S2
Entrez Gene ID: (Human) 252969