PA1-4304 detects the human NEI3 protein in human samples.
PA1-4304 has been successfully used in Western blot procedures. By Western blot this antibody detects a ~68 kDa protein representing NEI3 in human testis lysate.
PA1-4304 immunizing peptide corresponds to amino acid residues 164-177 of the human NEI3 protein. There is 85% sequence identity to mouse and rat.
Prokaryotes and lower eukaryotes possess redundant activities that remove the plethora of oxidative DNA base damages produced during normal oxidative metabolism and which have been associated with cancer and aging. Thus far, only one oxidized pyrimidine-specific DNA glycosylase has been identified in humans, hNthl. HNEI3 is one of three new putative human DNA glycosylases.
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Protein Aliases: DNA glycosylase FPG2; DNA glycosylase hFPG2; DNA glycosylase/AP lyase Neil3; Endonuclease 8-like 3; Endonuclease VIII-like 3; FGP2; FLJ10858; FPG2; hFPG2; hNEI3; nei endonuclease VIII-like 3; nei-like DNA glycosylase 3; Nei-like protein 3; NEI3; zinc finger, GRF-type containing 3
Gene Aliases: FGP2; FPG2; hFPG2; hNEI3; NEI3; NEIL3; ZGRF3
UniProt ID: (Human) Q8TAT5
Entrez Gene ID: (Human) 55247