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Immunogen sequence: MPSRAEDYE VLYTIGTGSY GRCQKIRRKS DGKILVWKEL DYGSMTEAEK QMLVSEVNLL RELKHPNIVR YYDRIIDRTN TTLYIVMEYC EGGDLASVIT KGTKERQYLD EEFVLRVMTQ LTLALKECHR RSDGGHTVLH RDLKPANVFL DGKQNVKLGD FGLARILNHD TSFAKTFVGT PYYMSPEQMN RMSYNEKSDI WSLGCLLYEL CALMPPFTAF SQKELAGKIR EGKFRRIPYR YSDELNEIIT RMLNLKDYHR PSVEEILENP LIADLVADEQ RRNLERRGRQ LGEPEKSQDS SPVLSELKLK EIQLQERERA LKAREERLEQ KEQELCVRER LAEDKLARAE NLLKNYSLLK ERKFLSLASN PELLNLPSSV IKKKVHFSGE SKENIMRSEN SESQLTSKSK CKDLKKRLHA AQLRAQALSD IEKNYQLKSR QILGMR (1-445 aa encoded by B C043502)
NEK2 is involved in cell cycle regulation and is essential for faithful chromosome segregation. NEK2 is a gene that encodes for a serine/threonine-protein kinase. This protein plays a crucial role in the regulation of mitosis and is primarily located in the centrosome. During the G1 phase, the protein is undetectable, but its levels progressively increase throughout the S phase, reaching their peak in late G2 phase. The gene has several alternatively spliced transcript variants that encode different isoforms with distinct C-termini. NEK2 is associated with several diseases, including Retinitis Pigmentosa 67 and Retinitis Pigmentosa.
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Protein Aliases: HSPK 21; NEK 2; NEK 2A; Nek2 kinase; Never in mitosis A-related kinase 2; NIMA (never in mitosis gene a)-related kinase 2; NIMA - related expressed kinase 2; NimA-like protein kinase 1; NIMA-related expressed kinase 2; NIMA-related kinase 2; NimA-related protein kinase 2; NLK 1; protein phosphatase 1, regulatory subunit 111; Serine/threonine-protein kinase Nek2
Gene Aliases: AA617254; C77054; HsPK21; NEK2; NEK2A; NLK1; PPP1R111; RP67