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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant protein fragment corresponding to a region within amino acids 185 and 349 of Human NEK2|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 1% BSA, 20% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||Assay-Dependent|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-31259 targets NEK2 in IF and WB applications and shows reactivity with Human samples.
The PA5-31259 immunogen is recombinant protein fragment corresponding to a region within amino acids 185 and 349 of Human NEK2.
Protein kinase that is involved in mitotic regulation. Integral component of the mitotic spindle-assembly checkpoint which is necessary for proper chromosome segregation during metaphase-anaphase transition. Required for association of MAD2L1 to kinetochore. Phosphorylates SGOL1. May have a role at the G2-M transition. May also play a role in meiosis. Isoform 1 but not isoform 2 appears to play a role in centrosome splitting. Isoform 1 phosphorylates and activates NEK11 in G1/S-arrested cells. Isoform 2, which is not present in the nucleolus, does not.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
HsPK21; NEK2A; NIMA (never in mitosis gene a)-related kinase 2; nimA-like protein kinase 1; NIMA-related kinase 2; nimA-related protein kinase 2; NLK1; protein phosphatase 1, regulatory subunit 111; serine/threonine-protein kinase Nek2
HsPK21; NEK2; NEK2A; NLK1; PPP1R111; RP67