PA5-28569 targets NEK3 in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-28569 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 255 of Human NEK3.
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This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. The kinase is activated by prolactin stimulation, leading to phosphorylation of VAV2 guanine nucleotide exchange factor, paxillin, and activation of the RAC1 GTPase. Multiple transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: glycogen synthase A kinase; HSPK 36; HSPK36; hydroxyalkyl-protein kinase; Never in mitosis A-related kinase 3; NIMA (never in mitosis gene a)-related kinase 3; NIMA-related kinase 3; NimA-related protein kinase 3; phosphorylase B kinase kinase; Serine/threonine-protein kinase Nek3
Gene Aliases: HSPK36; NEK3
UniProt ID: (Human) P51956
Entrez Gene ID: (Human) 4752