Immunogen sequence: LSTERELFAW GRGDSGRLGL GTRESHSCPQ QVPMPPGQEA QRVVCGIDSS MILTVPGQAL ACGSNRFNKL G
Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 86%.
Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia.Defects in NEK8 are the cause of nephronophthisis type 9 (NPHP9) [MIM:613824]. NPHP9 is an autosomal recessive disorder resulting in end-stage renal disease. It is a progressive tubulo-interstitial kidney disorder histologically characterized by modifications of the tubules with thickening of the basement membrane, interstitial fibrosis and, in the advanced stages, medullary cysts.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: juvenile cystic kidney; NEK 8; nephrocystin 9; Never in mitosis A-related kinase 8; NIMA (never in mitosis gene a)- related kinase 8; NIMA-family kinase NEK8; NIMA-related expressed kinase 8; NIMA-related kinase 12a; NIMA-related kinase 8; Nima-related protein kinase 12a; NimA-related protein kinase 8; Serine/threonine-protein kinase Nek8; serine/thrionine-protein kinase NEK8
Gene Aliases: 4632401F23Rik; b2b1449Clo; JCK; NEK12A; NEK8; NPHP9; RHPD2