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Product Details
12244-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
NELF Fusion Protein Ag2888 (1-287 aa encoded by BC016862)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody recognizes all the isoforms.
Immunogen sequence: ERKRRKREN DSASVIQRNF RKHLRMVGSR RVKAQTFAER RERSFSRSWS DPTPMKADTS HDSRDSSDLQ SSHCTLDEAF EDLDWDTEKG LEAVACDTEG FVPPKVMLIS SKVPKAEYIP TIIRRDDPSI IPILYDHEHA TFEDILEEIE RKLNVYHKGA KIWKMLIFCQ GGPGHLYLLK NKVATFAKVE KEEDMIHFWK RLSRLMSKVN PEPNVIHIMG CYILGNPNGE KLFQNLRTLM TPYRVTFESP LELSAQGKQM IETYFDFRLY RLWKSRQHSK LLDFDDVL (1-287 aa encoded by BC016862)
Target Information
NELF (nasal embryonic luteinizing hormone-releasing hormone factor) is a 530 amino acid transcription factor involved in the migration of LHRH neurons, outgrowth of olfactory axons and suppression of transcription elongation. NELF is found in the peripheral and central nervous system during embryonic development, and is highly expressed in adult testis, kidney and brain. Known to couple NMDA receptor signaling to the nucleus, NELF knockdown impaired GnRH neuronal migration of NLT cells in vitro and the gene encoding NELF has been linked to the development of Idiopathic hypogonadotropic hypogonadism (IHH), a disorder resulting in impaired pubertal maturation and reproductive function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Jacob protein; Juxtasynaptic attractor of caldendrin on dendritic boutons protein; Nasal embryonic LHRH factor; Nasal embryonic luteinizing hormone-releasing hormone factor; NMDA receptor synaptonuclear signaling and neuronal migration factor
Gene Aliases: HH9; Jac; Jacob; NELF; NSMF
UniProt ID: (Human) Q6X4W1, (Rat) Q9EPI6, (Mouse) Q99NF2
Entrez Gene ID: (Human) 26012, (Rat) 117536, (Mouse) 56876
positive regulation of protein dephosphorylation
regulation of neuron apoptotic process
regulation of neuronal synaptic plasticity
regulation of dendrite morphogenesis
cellular response to amino acid stimulus
cellular response to electrical stimulus
cellular response to gonadotropin stimulus
positive regulation of neuron migration
biological_process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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