This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: KLNVYHKGAK IWKMLIFCQG GPGHLYLLKN KVATFAKVEK EEDMIHFWKR LSRLMSKVNP EPNVIHIMGC YILGNPNGEK LFQNLRTLMT PYRVTFESPL ELSAQGKQMI ETYFDFRL
Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 98%.
NELF (nasal embryonic luteinizing hormone-releasing hormone factor) is a 530 amino acid transcription factor involved in the migration of LHRH neurons, outgrowth of olfactory axons and suppression of transcription elongation. NELF is found in the peripheral and central nervous system during embryonic development, and is highly expressed in adult testis, kidney and brain. Known to couple NMDA receptor signaling to the nucleus, NELF knockdown impaired GnRH neuronal migration of NLT cells in vitro and the gene encoding NELF has been linked to the development of Idiopathic hypogonadotropic hypogonadism (IHH), a disorder resulting in impaired pubertal maturation and reproductive function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Nasal embryonic LHRH factor; Nasal embryonic luteinizing hormone-releasing hormone factor; NELF; NMDA receptor synaptonuclear signaling and neuronal migration factor
Gene Aliases: HH9; NELF; NSMF
UniProt ID: (Human) Q6X4W1
Entrez Gene ID: (Human) 26012