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Immunogen sequence: SLCAHKAGCQ VASTMLVWSK DDGVSWSTPR NLSLDIGTEV FAPGPGSGIQ KQREPRKGRL IVCGHGTLER DGVFCLLSDD HGASWRYGSG VSGIPYGQPK QENDFNPDEC QPYELPDGSV VINARNQNNY HCHCRIVLRS YDACDTLRPR DVTFDPELVD PVVAAGAVVT SSGIVFFSNP AHPEFRVNLT LRWSFSNGTS WRKETVQLWP GPSGYSSLAT LEGSMDGEEQ APQLYVLYEK GRNHYTESIS VAKISVYGTL; Positive Samples: Mouse liver, Rat liver; Cellular Location: Cell membrane, Cytoplasmic vesicle, Lumenal side, Lysosome lumen, Lysosome membrane, Peripheral membrane protein
NEU1 is a lysosomal enzyme, which cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A. Mutations in NEU1 gene can lead to sialidosis.The protein encoded by this gene encodes the lysosomal enzyme, which cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A (the latter also referred to as 'protective protein'). Mutations in this gene can lead to sialidosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: EC 3.2.1.18; FLJ93471; G9 sialidase; HLA-B-associated transcript 7; Lysosomal sialidase; N-acetyl-alpha-neuraminidase 1; sialidase 1; sialidase 1 (lysosomal sialidase); Sialidase-1
Gene Aliases: AA407268; AA407316; Aglp; Apl; Bat-7; Bat7; G9; Map-2; Neu; Neu-1; Neu1
UniProt ID: (Mouse) O35657
Entrez Gene ID: (Mouse) 18010, (Rat) 24591
Molecular Function:
hydrolase
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