Proteintech

NEU4 Polyclonal Antibody

NEU4 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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NEU4 Antibody (12995-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human placenta tissue slide using (Product # 12995-1-AP) (NEU4 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

NEU4 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

12995-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 7 publications 7 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

NEU4 Fusion Protein Ag3657 (158-496 aa encoded by BC012899)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.35 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: AIGGAVQDW ATFAVGPGHG VQLPSGRLLV PAYTYRVDRR ECFGKICRTS PHSFAFYSDD HGRTWRCGGL VPNLRSGECQ LAAVDGGQAG SFLYCNARSP LGSRVQALST DEGTSFLPAE RVASLPETAW GCQGSIVGFP APAPNRPRDD SWSVGPGSPL QPPLLGPGVH EPPEEAAVDP RGGQVPGGPF SRLQPRGDGP RQPGPRPGVS GDVGSWTLAL PMPFAAPPQS PTWLLYSHPV GRRARLHMGI RLSQSPLDPR SWTEPWVIYE GPSGYSDLAS IGPAPEGGLV FACLYESGAR TSYDEISFCT FSLREVLENV PASPKPPNLG DKPRGCCWPS (158-496 aa encoded by BC012899)

Target Information

The protein encoded by this gene belongs to a family of glycohydrolytic enzymes, which remove terminal sialic acid residues from various sialo derivatives, such as glycoproteins, glycolipids, oligosaccharides, and gangliosides. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

A novel insulin receptor-signaling platform and its link to insulin resistance and type 2 diabetes.

Cellular signalling

Alghamdi F,Guo M,Abdulkhalek S,Crawford N,Amith SR,Szewczuk MR

Sun Jun 01 00:00:00 UTC 2014

A novel insulin receptor-signaling platform and its link to insulin resistance and type 2 diabetes.

Cellular signalling

Alghamdi F,Guo M,Abdulkhalek S,Crawford N,Amith SR,Szewczuk MR

Sun Jun 01 00:00:00 UTC 2014

A novel insulin receptor-signaling platform and its link to insulin resistance and type 2 diabetes.

Cellular signalling

Alghamdi F,Guo M,Abdulkhalek S,Crawford N,Amith SR,Szewczuk MR

Sun Jun 01 00:00:00 UTC 2014

A novel insulin receptor-signaling platform and its link to insulin resistance and type 2 diabetes.

Cellular signalling

Alghamdi F,Guo M,Abdulkhalek S,Crawford N,Amith SR,Szewczuk MR

Sun Jun 01 00:00:00 UTC 2014

A novel epidermal growth factor receptor-signaling platform and its targeted translation in pancreatic cancer.

Cellular signalling

Gilmour AM,Abdulkhalek S,Cheng TS,Alghamdi F,Jayanth P,O'Shea LK,Geen O,Arvizu LA,Szewczuk MR

Sun Dec 01 00:00:00 UTC 2013

A novel epidermal growth factor receptor-signaling platform and its targeted translation in pancreatic cancer.

Cellular signalling

Gilmour AM,Abdulkhalek S,Cheng TS,Alghamdi F,Jayanth P,O'Shea LK,Geen O,Arvizu LA,Szewczuk MR

Sun Dec 01 00:00:00 UTC 2013

A novel epidermal growth factor receptor-signaling platform and its targeted translation in pancreatic cancer.

Cellular signalling

Gilmour AM,Abdulkhalek S,Cheng TS,Alghamdi F,Jayanth P,O'Shea LK,Geen O,Arvizu LA,Szewczuk MR

Sun Dec 01 00:00:00 UTC 2013

A novel epidermal growth factor receptor-signaling platform and its targeted translation in pancreatic cancer.

Cellular signalling

Gilmour AM,Abdulkhalek S,Cheng TS,Alghamdi F,Jayanth P,O'Shea LK,Geen O,Arvizu LA,Szewczuk MR

Sun Dec 01 00:00:00 UTC 2013

Macrophages discriminate glycosylation patterns of apoptotic cell-derived microparticles.

The Journal of biological chemistry

Bilyy RO,Shkandina T,Tomin A,Muñoz LE,Franz S,Antonyuk V,Kit YY,Zirngibl M,Fürnrohr BG,Janko C,Lauber K,Schiller M,Schett G,Stoika RS,Herrmann M

Mon Jan 02 00:00:00 UTC 2012

Macrophages discriminate glycosylation patterns of apoptotic cell-derived microparticles.

The Journal of biological chemistry

Bilyy RO,Shkandina T,Tomin A,Muñoz LE,Franz S,Antonyuk V,Kit YY,Zirngibl M,Fürnrohr BG,Janko C,Lauber K,Schiller M,Schett G,Stoika RS,Herrmann M

Mon Jan 02 00:00:00 UTC 2012

Neu1 sialidase and matrix metalloproteinase-9 cross-talk is essential for neurotrophin activation of Trk receptors and cellular signaling.

Cellular signalling

Jayanth P,Amith SR,Gee K,Szewczuk MR

Sun Aug 01 00:00:00 UTC 2010

Neu1 sialidase and matrix metalloproteinase-9 cross-talk is essential for neurotrophin activation of Trk receptors and cellular signaling.

Cellular signalling

Jayanth P,Amith SR,Gee K,Szewczuk MR

Sun Aug 01 00:00:00 UTC 2010

Neu1 sialidase and matrix metalloproteinase-9 cross-talk is essential for neurotrophin activation of Trk receptors and cellular signaling.

Cellular signalling

Jayanth P,Amith SR,Gee K,Szewczuk MR

Sun Aug 01 00:00:00 UTC 2010

Neu1 sialidase and matrix metalloproteinase-9 cross-talk is essential for neurotrophin activation of Trk receptors and cellular signaling.

Cellular signalling

Jayanth P,Amith SR,Gee K,Szewczuk MR

Sun Aug 01 00:00:00 UTC 2010

Thymoquinone-induced Neu4 sialidase activates NFκB in macrophage cells and pro-inflammatory cytokines in vivo.

Glycoconjugate journal

Finlay TM,Abdulkhalek S,Gilmour A,Guzzo C,Jayanth P,Amith SR,Gee K,Beyaert R,Szewczuk MR

Sun Aug 01 00:00:00 UTC 2010

Thymoquinone-induced Neu4 sialidase activates NFκB in macrophage cells and pro-inflammatory cytokines in vivo.

Glycoconjugate journal

Finlay TM,Abdulkhalek S,Gilmour A,Guzzo C,Jayanth P,Amith SR,Gee K,Beyaert R,Szewczuk MR

Sun Aug 01 00:00:00 UTC 2010

Thymoquinone from nutraceutical black cumin oil activates Neu4 sialidase in live macrophage, dendritic, and normal and type I sialidosis human fibroblast cells via GPCR Galphai proteins and matrix metalloproteinase-9.

Glycoconjugate journal

Finlay TM,Jayanth P,Amith SR,Gilmour A,Guzzo C,Gee K,Beyaert R,Szewczuk MR

Thu Apr 01 00:00:00 UTC 2010

Glycoconjugate journal

Finlay TM,Jayanth P,Amith SR,Gilmour A,Guzzo C,Gee K,Beyaert R,Szewczuk MR

Thu Apr 01 00:00:00 UTC 2010

Dependence of pathogen molecule-induced toll-like receptor activation and cell function on Neu1 sialidase.

Glycoconjugate journal

Amith SR,Jayanth P,Franchuk S,Siddiqui S,Seyrantepe V,Gee K,Basta S,Beyaert R,Pshezhetsky AV,Szewczuk MR

Tue Dec 01 00:00:00 UTC 2009

Dependence of pathogen molecule-induced toll-like receptor activation and cell function on Neu1 sialidase.

Glycoconjugate journal

Amith SR,Jayanth P,Franchuk S,Siddiqui S,Seyrantepe V,Gee K,Basta S,Beyaert R,Pshezhetsky AV,Szewczuk MR

Tue Dec 01 00:00:00 UTC 2009

Dependence of pathogen molecule-induced toll-like receptor activation and cell function on Neu1 sialidase.

Glycoconjugate journal

Amith SR,Jayanth P,Franchuk S,Siddiqui S,Seyrantepe V,Gee K,Basta S,Beyaert R,Pshezhetsky AV,Szewczuk MR

Tue Dec 01 00:00:00 UTC 2009

Dependence of pathogen molecule-induced toll-like receptor activation and cell function on Neu1 sialidase.

Glycoconjugate journal

Amith SR,Jayanth P,Franchuk S,Siddiqui S,Seyrantepe V,Gee K,Basta S,Beyaert R,Pshezhetsky AV,Szewczuk MR

Tue Dec 01 00:00:00 UTC 2009

Bioinformatics

Protein Aliases: N-acetyl-alpha-neuraminidase 4; neuraminidase 4 (sialidase); sialidase 4; Sialidase-4

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Gene Aliases: LP5125; NEU4

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UniProt ID: (Human) Q8WWR8

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Entrez Gene ID: (Human) 129807

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Function(s)

exo-alpha-sialidase activity protein binding exo-alpha-(2->3)-sialidase activity exo-alpha-(2->6)-sialidase activity exo-alpha-(2->8)-sialidase activity hydrolase

Process(es)

glycoprotein catabolic process glycosphingolipid metabolic process ganglioside catabolic process oligosaccharide catabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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NEU4 Polyclonal Antibody

NEU4 Antibody (12995-1-AP) in IHC (P)

Product Details

12995-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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