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NF-H Polyclonal Antibody
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FIGURE: 1 / 7
NF-H Antibody (PA1-10002) in IHC (F)
Immunohistochemical analysis of human skin stained with Neurofilament, Heavy chain Polyclonal Antibody (Product # PA1-10002). Free-floating, formalin-fixed frozen human skin tissue sections (60 µm) were stained with PA1-10002 (1:2000) followed by a fluorescently-conjugated donkey anti-chicken IgY secondary antibody. Tissues were visualized by confocal microscopy. Data courtesy of the Innovators Program.
Product Details
PA1-10002
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Dog,
Horse,
Human,
Mouse,
Pig,
Rat
Published species
Human,
Mouse
Host/Isotype
Chicken
/ IgY
Class
Polyclonal
Type
Antibody
Immunogen
Native NF-H purified from bovine spinal cord.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody reacts primarily with the phosphorylated axonal form of NF-H and shows some cross-reactivity with phosphorylated NF-M, which has similar phosphorylation sites to NF-H.
Target Information
Involved in the maintenance of neuronal caliber, neurofilaments are the intermediate filament proteins found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H. Like most other intermediate filament proteins (IFPs), the expression of the different neuronal IFPs is both tissue-specific and developmentally regulated. NF-H has an important role in mature axons and is involved in amyotrophic lateral sclerosis (ALS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 200 kDa neurofilament protein; heavy neurofilament protein; hSTEp; intermediate filament protein; NEF3; neurofilament; neurofilament 200kDa; Neurofilament heavy polypeptide; Neurofilament triplet H protein; neurofilament, heavy polypeptide 200kDa; NF 200 kD; NF-H; NHC; unnamed protein product
Gene Aliases: CMT2CC; KIAA0845; mKIAA0845; NEFH; NF-H; NF200; NFH
UniProt ID: (Human) P12036, (Mouse) P19246
Entrez Gene ID: (Dog) 442940, (Horse) 100064328, (Human) 4744, (Pig) 100156492, (Rat) 24587, (Mouse) 380684
structural constituent of cytoskeleton
protein binding
microtubule binding
kinesin binding
protein kinase binding
protein binding, bridging
dynein complex binding
structural constituent of postsynaptic intermediate filament cytoskeleton
structural molecule activity
toxic substance binding
nutrient reservoir activity
protein heterodimerization activity
microtubule cytoskeleton organization
axonogenesis
cell projection assembly
neurofilament bundle assembly
intermediate filament cytoskeleton organization
intermediate filament bundle assembly
peripheral nervous system neuron axonogenesis
neurofilament cytoskeleton organization
axon development
postsynaptic modulation of chemical synaptic transmission
postsynaptic intermediate filament cytoskeleton organization
regulation of organelle transport along microtubule
cellular response to leukemia inhibitory factor
ovarian follicle atresia
brain development
embryo development
spinal cord development
axon regeneration
neuron projection development
cellular response to oxidative stress
response to cocaine
cellular response to estradiol stimulus
response to sodium arsenite
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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