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Proteintech
NFKB1 p105/p50 Polyclonal Antibody
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Product Details
14220-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Published species
Chicken,
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
NF-kappaB Fusion Protein Ag5458 (1-368 aa encoded by BC051765)
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Amount
45 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody can bind both p105 and p50 isoforms of NFKB1.
Immunogen sequence: MAEDDPYLG RPEQMFHLDP SLTHTIFNPE VFQPQMALPT ADGPYLQILE QPKQRGFRFR YVCEGPSHGG LPGASSEKNK KSYPQVKICN YVGPAKVIVQ LVTNGKNIHL HAHSLVGKHC EDGICTVTAG PKDMVVGFAN LGILHVTKKK VFETLEARMT EACIRGYNPG LLVHPDLAYL QAEGGGDRQL GDREKELIRQ AALQQTKEMD LSVVRLMFTA FLPDSTGSFT RRLEPVVSDA IYDSKAPNAS NLKIVRMDRT AGCVTGGEEI YLLCDKVQKD DIQIRFYEEE ENGGVWEGFG DFSPTDVHRQ FAIVFKTPKY KDINITKPAS VFVQLRRKSD LETSEPKPFL YYPEIKDKEE VQRKRQKLM (1-368 aa encoded by BC051765 )
Target Information
NF-kB is a nuclear transcription factor activated by various extra and intracellular stimuli such as cytokines, UV radiation, stress, in injury, and by bacterial and viral products. It is involved in regulation of various cellular events including cell growth, differentiation, proliferation, apoptosis and inflammation. NFKB1 (p50), a 50KDa functional sub-unit of NF-kB, is a member of Rel protein family. It is synthesized as a p105 precursor protein and consists of an N-terminal conserved RHD-region containing nuclear localization signal, DNA-binding and dimerization domains. NFKB1 (p50) forms homodimers or heterodimerizes with p65, forming the functional NF-kB factor. NFKB1 (p50) directs the nuclear translocation of NF-kB and is instrumental in its DNA-bidning. Pathological role of NF-kB has been suggested in AIDS, hematogenic cancer cell metastasis and rheumatoid arthritis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DKFZp686C01211; DNA-binding factor KBF1; EBP-1; MGC54151; NF KB; NF-kB p50/p105; nuclear factor; nuclear factor kappa b; nuclear factor kappa-B DNA binding subunit; Nuclear factor NF-kappa-B p105 subunit; nuclear factor NF-kappa-B p50 subunit; nuclear factor of kappa light chain gene enhancer in B-cells 1, p105; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105; unnamed protein product
Gene Aliases: CVID12; EBP-1; KBF1; NF-kappa-B1; NF-kappaB; NF-kappabeta; NF-kB; NF-kB1; NFkappaB; NFKB-p105; NFKB-p50; NFKB1
UniProt ID: (Human) P19838, (Rat) Q63369
Entrez Gene ID: (Human) 4790, (Rat) 81736
transcription regulatory region sequence-specific DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription coactivator binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription cofactor activity
protein binding
identical protein binding
actinin binding
sequence-specific DNA binding
protein sequestering activity
regulatory region DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
double-stranded DNA binding
transcription factor binding
heat shock protein binding
protein homodimerization activity
transcription regulatory region DNA binding
protein heterodimerization activity
Rel homology transcription factor
negative regulation of transcription from RNA polymerase II promoter
MAPK cascade
negative regulation of cytokine production
immune system process
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
apoptotic process
inflammatory response
signal transduction
I-kappaB kinase/NF-kappaB signaling
JNK cascade
gene expression
regulation of gene expression
positive regulation of macromolecule biosynthetic process
negative regulation of gene expression
positive regulation of macrophage derived foam cell differentiation
positive regulation of cholesterol efflux
positive regulation of lipid storage
negative regulation of vitamin D biosynthetic process
signal transduction involved in regulation of gene expression
negative regulation of interleukin-12 production
tumor necrosis factor-mediated signaling pathway
response to muscle stretch
NIK/NF-kappaB signaling
negative regulation of apoptotic process
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of inflammatory response
positive regulation of inflammatory response
B cell receptor signaling pathway
mammary gland involution
positive regulation of transcription initiation from RNA polymerase II promoter
cellular response to lipopolysaccharide
cellular response to mechanical stimulus
cellular response to nicotine
cellular response to cytokine stimulus
cellular response to interleukin-6
cellular response to tumor necrosis factor
cellular response to dsRNA
positive regulation of canonical Wnt signaling pathway
cellular response to interleukin-17
cellular response to virus
antibacterial innate immune response
negative regulation of cytokine production involved in inflammatory response
positive regulation of hyaluronan biosynthetic process
cellular response to angiotensin
positive regulation of miRNA metabolic process
response to oxidative stress
response to bacterium
negative regulation of calcidiol 1-monooxygenase activity
response to cytokine
negative regulation of interleukin-12 biosynthetic process
innate immune response
response to copper ion
cellular response to interleukin-1
cellular response to peptide hormone stimulus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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