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Invitrogen
NF2 Polyclonal Antibody
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Product Details
PA5-82060
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human NF2. Recombinant protein control fragment (Product #RP-91529).
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: ERRAKQKLLE IATKPTYPPM NPIPAPLPPD IPSFNLIGDS LSFDFKDTDM KRLSMEIEKE KVEYMEKSKH LQEQLNELKT EIEALKLKER ETALDILHNE NSDRGGSSKH NTIKKLTLQS AKSRVA
Highest antigen sequence indentity to the following orthologs: Mouse - 94%, Rat - 88%.
Target Information
NF2 encodes a protein, Merlin, that is similar to some members of the ERM family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. Merlin has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: bilateral acoustic neurofibromatosis; Merlin; MGC123124; moesin-ezrin-radixin like; Moesin-ezrin-radixin-like protein; moesin-ezrin-radizin-like protein; neurofibromatosis 2; neurofibromatosis type 2; neurofibromin 2 (bilateral acoustic neuroma); Neurofibromin-2; NF2; OTTHUMP00000199607; Schwannomerlin; Schwannomin; tumor suppressor; tumor suppressor; bilateral acoustic neuroma; Schwannomin/Merlin/Schwannomerlin; unnamed protein product
Gene Aliases: ACN; BANF; merlin; merlin-1; Nf-2; NF2; SCH; SWNV
UniProt ID: (Human) P35240, (Mouse) P46662, (Rat) Q63648
Entrez Gene ID: (Human) 4771, (Mouse) 18016, (Rat) 25744
MAPK cascade
mesoderm formation
negative regulation of cell-matrix adhesion
ectoderm development
brain development
negative regulation of cell proliferation
regulation of cell shape
negative regulation of Schwann cell proliferation
Schwann cell proliferation
regulation of gliogenesis
hippocampus development
negative regulation of cell-cell adhesion
actin cytoskeleton organization
cell differentiation
negative regulation of cell migration
regulation of protein stability
osteoblast proliferation
negative regulation of osteoblast proliferation
regulation of hippo signaling
regulation of cell proliferation
odontogenesis of dentin-containing tooth
regulation of apoptotic process
negative regulation of MAPK cascade
cell-cell junction organization
positive regulation of cell differentiation
negative regulation of JAK-STAT cascade
regulation of neurogenesis
positive regulation of stress fiber assembly
regulation of cell cycle
lens fiber cell differentiation
regulation of stem cell proliferation
regulation of protein localization to nucleus
regulation of organelle assembly
positive regulation of protein localization to early endosome
regulation of neural precursor cell proliferation
positive regulation of early endosome to late endosome transport
negative regulation of protein kinase activity
negative regulation of DNA replication
negative regulation of cell growth
negative regulation of tyrosine phosphorylation of Stat3 protein
negative regulation of tyrosine phosphorylation of Stat5 protein
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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