PA1-4196 detects NFATc1 in human samples. NFATc1 is also known as NFAT2 or NFATc.
PA1-4196 has been successfully used in Western blot procedures.
The PA1-4196 immunogen is a synthetic peptide corresponding to residues S(211) P K T T D P E E G F P R(223) of human NFATc1.
The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: calcineurin-dependent 1; cytoplasmic; MGC138448; NF-ATC; NF-ATc1; NFAT tra; NFAT transcription complex cytosolic component; NFAT2; NFATC; NFATC1; nuclear factor of activated T-cells; nuclear factor of activated T-cells 'c'; Nuclear factor of activated T-cells, cytoplasmic 1; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
Gene Aliases: NF-ATC; NF-ATc1.2; NFAT2; NFATC; NFATC1
UniProt ID: (Human) O95644
Entrez Gene ID: (Human) 4772
Molecular Function: transcription factor