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Proteintech
NFATC3 Polyclonal Antibody
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Product Details
18222-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
NFATC3 Fusion Protein Ag12985 (1-205 aa encoded by BC001050)
Conjugate
Form
Liquid
Concentration
0.34 mg/mL
Amount
51 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MTTANCGAH DELDFKLVFG EDGAPAPPPP GSRPADLEPD DCASIYIFNV DPPPSTLTTP LCLPHHGLPS HSSVLSPSFQ LQSHKNYEGT CEIPESKYSP LGGPKPFECP SIQITSISPN CHQELDAHED DLQINDPERE FLERPSRDHL YLPLEPSYRE SSLSPSPASS ISSRSWFSDA SSCESLSHIY DDVDSELNEA AARFTL (1-205 aa encoded by B C001050)
Target Information
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: alternative splicing form; NF-AT4; NF-ATc3; NFAC3; NFATx; NFC3; Nuclear factor of activated T-cells, cytoplasmic 3; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3; T cell transcription factor NFAT4; T-cell transcription factor NFAT4; transcription factor; unnamed protein product
Gene Aliases: C80703; D8Ertd281e; n339260; NF-AT4c; NFAT4; NFATC3; NFATX
UniProt ID: (Human) Q12968
Entrez Gene ID: (Human) 4775, (Mouse) 18021
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific double-stranded DNA binding
core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
chromatin binding
transcription factor binding
sequence-specific DNA binding
Rel homology transcription factor
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
inflammatory response
calcineurin-NFAT signaling cascade
positive thymic T cell selection
positive regulation of nitric oxide biosynthetic process
positive regulation of transcription from RNA polymerase II promoter
negative regulation of pri-miRNA transcription from RNA polymerase II promoter
DN4 thymocyte differentiation
negative regulation of vascular smooth muscle cell differentiation
positive regulation of artery morphogenesis
patterning of blood vessels
response to hypoxia
blood vessel remodeling
transcription, DNA-templated
transcription from RNA polymerase II promoter
heart development
cardiac muscle hypertrophy in response to stress
myotube differentiation
myotube cell development
T cell differentiation
cellular respiration
positive regulation of transcription, DNA-templated
thymus development
skeletal muscle fiber development
smooth muscle cell differentiation
muscle cell development
cellular response to calcium ion
cellular response to lithium ion
regulation of store-operated calcium entry
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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