Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
NFATC3 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Product Details
PA5-78403
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of mouse NFAT4. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1.41 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Control: Jurkat, Raji, NCI-H929, mouse thymus
Predicted Reactivity: Human (90%), Rat (96%), Bovine (92%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: NF-AT4; NF-ATc3; NFAC3; NFATx; NFC3; nuclear factor of activated T-cells c3 isoform IE-Xa; Nuclear factor of activated T-cells, cytoplasmic 3; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3; T cell transcription factor NFAT4; T-cell transcription factor NFAT4
Gene Aliases: C80703; D8Ertd281e; NFAT4; NFATC3; NFATX
UniProt ID: (Human) Q12968
Entrez Gene ID: (Human) 4775, (Mouse) 18021
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
protein binding
core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription factor binding
sequence-specific DNA binding
Rel homology transcription factor
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
inflammatory response
Fc-epsilon receptor signaling pathway
positive regulation of transcription from RNA polymerase II promoter
negative regulation of pri-miRNA transcription from RNA polymerase II promoter
patterning of blood vessels
response to hypoxia
blood vessel remodeling
transcription, DNA-templated
regulation of transcription, DNA-templated
heart development
cardiac muscle hypertrophy in response to stress
myotube differentiation
myotube cell development
T cell differentiation
calcineurin-NFAT signaling cascade
cellular respiration
positive regulation of transcription, DNA-templated
thymus development
skeletal muscle fiber development
smooth muscle cell differentiation
muscle cell development
cellular response to calcium ion
cellular response to lithium ion
regulation of store-operated calcium entry
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support