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Invitrogen

NFATC3 Polyclonal Antibody

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View all (13) NFATC3 antibodies

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NFATC3 Polyclonal Antibody

Product Details

PA5-99546

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunocytochemistry (ICC/IF)

1:100-1:500
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human NFATC3(Accession Q12968), corresponding to amino acid residues E139-Y189.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2818479

Product Specific Information

Antibody detects endogenous levels of total NFAT4.

Target Information

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: alternative splicing form; NF-AT4; NF-ATc3; NFAC3; NFATx; NFC3; Nuclear factor of activated T-cells, cytoplasmic 3; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3; T cell transcription factor NFAT4; T-cell transcription factor NFAT4; transcription factor; unnamed protein product

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Gene Aliases: C80703; D8Ertd281e; n339260; NF-AT4c; NFAT4; NFATC3; NFATX

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UniProt ID: (Human) Q12968

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Entrez Gene ID: (Human) 4775, (Mouse) 18021

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding sequence-specific double-stranded DNA binding core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding chromatin binding transcription factor binding sequence-specific DNA binding Rel homology transcription factor
Process(es)
negative regulation of transcription from RNA polymerase II promoter regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter inflammatory response calcineurin-NFAT signaling cascade positive thymic T cell selection positive regulation of nitric oxide biosynthetic process positive regulation of transcription from RNA polymerase II promoter negative regulation of pri-miRNA transcription from RNA polymerase II promoter DN4 thymocyte differentiation negative regulation of vascular smooth muscle cell differentiation positive regulation of artery morphogenesis patterning of blood vessels response to hypoxia blood vessel remodeling transcription, DNA-templated transcription from RNA polymerase II promoter heart development cardiac muscle hypertrophy in response to stress myotube differentiation myotube cell development T cell differentiation cellular respiration positive regulation of transcription, DNA-templated thymus development skeletal muscle fiber development smooth muscle cell differentiation muscle cell development cellular response to calcium ion cellular response to lithium ion regulation of store-operated calcium entry
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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