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Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
NF-1, also designated CTF, consists of a family of CCAAT box binding proteins that stimulate DNA replication and activate transcription. Analysis of human NF-1 messenger RNA has revealed two forms of the NF-1 protein arising from an alternate splicing of a single NF-1 gene. NF-1 binds its consensus DNA element as a homodimer via an amino-terminal DNA binding domain, and activates transcription through a putatively novel, proline-rich, carboxy terminal transactivation domain. The NF-1 protein has been shown to recognize and bind the adenovirus type 2 promoter and activate transcription of herpes simplex virus thymidine kinase genes. The NF-1 consensus element has been found in the upstream promoter region of myriad eukaryotic genes, including that of Ha-Ras, alpha-globin, HSP 70, GRP 78, Histone H1, myelin basic protein and in the Xenopus laevis vitellogenin gene promoter.
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Protein Aliases: CCAAT-box-binding transcription factor; CTF; NF-I/B; NF1-B; Nuclear factor 1 B-type; nuclear factor 1/B; Nuclear factor I/B; olfactory epithelium nuclear factor I-B; TGGCA-binding protein
Gene Aliases: 6720429L07Rik; CTF; E030026I10Rik; HMGIC/NFIB; NF-I/B; NF1-B; NFI-B; NFI-RED; NFIB; NFIB2; NFIB3