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Invitrogen
NFIB Polyclonal Antibody
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Product Details
PA5-86065
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein within Human NFIB aa 1-273
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 50% Glycerol, 0.2% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
NF-1, also designated CTF, consists of a family of CCAAT box binding proteins that stimulate DNA replication and activate transcription. Analysis of human NF-1 messenger RNA has revealed two forms of the NF-1 protein arising from an alternate splicing of a single NF-1 gene. NF-1 binds its consensus DNA element as a homodimer via an amino-terminal DNA binding domain, and activates transcription through a putatively novel, proline-rich, carboxy terminal transactivation domain. The NF-1 protein has been shown to recognize and bind the adenovirus type 2 promoter and activate transcription of herpes simplex virus thymidine kinase genes. The NF-1 consensus element has been found in the upstream promoter region of myriad eukaryotic genes, including that of Ha-Ras, alpha-globin, HSP 70, GRP 78, Histone H1, myelin basic protein and in the Xenopus laevis vitellogenin gene promoter.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CCAAT-box-binding transcription factor; CTF; NF-I/B; NF1-B; Nuclear factor 1 B-type; nuclear factor 1/B; Nuclear factor I/B; TGGCA-binding protein
Gene Aliases: 6720429L07Rik; CTF; E030026I10Rik; HMGIC/NFIB; NF-I/B; NF1-B; NFI-B; NFI-RED; NFIB; NFIB2; NFIB3
UniProt ID: (Human) O00712, (Mouse) P97863
Entrez Gene ID: (Human) 4781, (Mouse) 18028
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
RNA polymerase II transcription corepressor activity
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
DNA-binding transcription factor
gene-specific transcriptional regulator
chondrocyte differentiation
DNA replication
transcription from RNA polymerase II promoter
glial cell differentiation
principal sensory nucleus of trigeminal nerve development
anterior commissure morphogenesis
hindbrain development
positive regulation of transcription from RNA polymerase II promoter
Clara cell differentiation
Type I pneumocyte differentiation
Type II pneumocyte differentiation
salivary gland cavitation
cell differentiation involved in salivary gland development
lung ciliated cell differentiation
commissural neuron axon guidance
negative regulation of pri-miRNA transcription from RNA polymerase II promoter
negative regulation of mesenchymal cell proliferation involved in lung development
negative regulation of epithelial cell proliferation involved in lung morphogenesis
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
negative regulation of cell proliferation
lung development
forebrain development
negative regulation of DNA binding
positive regulation of transcription, DNA-templated
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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