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NFIB/NF1B2 Polyclonal Antibody

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Product Details

BS-11899R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:300
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-

Flow Cytometry (Flow)

1:20-1:100
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human NFIB/NF1B2, amino acids 1-100.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

NFIB (Nuclear Factor I B) is a member of the Nuclear Factor I (NFI) family of transcription factors that play critical roles in DNA replication and gene regulation. NFIB is widely involved in developmental processes, including lung and brain maturation, and has been implicated in tumorigenesis, where altered expression or rearrangements can influence cell proliferation, differentiation, and metastatic potential. NF1B2, a related isoform/variant within the NFI family context, contributes to the fine-tuning of transcriptional regulation through differential expression and functional modulation. Together, NFIB and NF1B2 are important regulators of gene networks governing cellular development, tissue-specific differentiation, and disease-associated pathways, making them significant targets for both basic biological research and translational studies.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CCAAT-box-binding transcription factor; CTF; NF-I/B; NF1-B; Nuclear factor 1 B-type; nuclear factor 1/B; Nuclear factor I/B; olfactory epithelium nuclear factor I-B; TGGCA-binding protein; transcription factor; unnamed protein product

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Gene Aliases: 6720429L07Rik; CTF; E030026I10Rik; HMGIC/NFIB; MACID; NF-I/B; NF1-B; NFI-B; NFI-RED; NFIB; NFIB2; NFIB3

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UniProt ID: (Human) O00712, (Mouse) P97863

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Entrez Gene ID: (Human) 4781, (Mouse) 18028, (Rat) 29227

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding protein binding transcription regulator inhibitor activity sequence-specific double-stranded DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription corepressor activity DNA-binding transcription factor gene-specific transcriptional regulator
Process(es)
negative regulation of transcription from RNA polymerase II promoter tissue homeostasis chondrocyte differentiation glandular epithelial cell differentiation DNA replication regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter brain development cell proliferation response to wounding response to bacterium glial cell differentiation exit from mitosis gene expression glial cell proliferation stem cell population maintenance principal sensory nucleus of trigeminal nerve development glial cell fate specification cell proliferation in forebrain anterior commissure morphogenesis neurogenesis lung development forebrain development hindbrain development regeneration negative regulation of DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter neuron fate specification generation of neurons retina development in camera-type eye Clara cell differentiation Type I pneumocyte differentiation Type II pneumocyte differentiation salivary gland cavitation cell differentiation involved in salivary gland development lung ciliated cell differentiation neural precursor cell proliferation commissural neuron axon guidance stem cell proliferation negative regulation of pri-miRNA transcription from RNA polymerase II promoter negative regulation of stem cell proliferation negative regulation of mesenchymal cell proliferation involved in lung development negative regulation of epithelial cell proliferation involved in lung morphogenesis transcription, DNA-templated transcription from RNA polymerase II promoter negative regulation of cell proliferation sensory perception of smell negative regulation of transcription, DNA-templated
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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