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Product Details
11273-1-AP
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
NFKBIE Fusion Protein Ag1800 (63-423 aa encoded by BC011676)
Conjugate
Form
Liquid
Concentration
0.23 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MSEARKGPD EAEESQYDSG IESLRSLRSL PESTSAPASG PSDGSPQPCT HPPGPVKEPQ EKEDADGERA DSTYGSSSLT YTLSLLGGPE AEDPAPRLPL PHVGALSPQQ LEALTYISED GDTLVHLAVI HEAPAVLLCC LALLPQEVLD IQNNLYQTAL HLAVHLDQPG AVRALVLKGA SRALQDRHGD TALHVACQRQ HLACARCLLE GRPEPGRGTS HSLDLQLQNW QGLACLHIAT LQKNQPLMEL LLRNGADIDV QEGTSGKTAL HLAVETQERG LVQFLLQAGA QVDARMLNGC TPLHLAAGRG LMGISSTLCK AGADSLLRNV EDETPQDLTE ESLVLLPFDD LKISGKLLLC TD (63-423 aa encoded by BC011676)
Target Information
NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008 or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine). For some genes, activation requires NFKB interaction with other transcription factors, such as STAT (see STAT6, MIM 601512), AP1 (JUN, MIM 165160), and NFAT (see NFATC1, MIM 600489).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: I-kappa-B-epsilon; ikappaBepsilon; IkB epsilon; IkB-E; ikB-epsilon; IkBepsilon; NF-kappa-B inhibitor epsilon; NF-kappa-BIE; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon; solute carrier family 35, member B2
Gene Aliases: I-kappa-B-epsilon; IkB-E; ikB-epsilon; IKBE; NF-kappa-BIE; NFKBIE; Slc35b2
UniProt ID: (Human) O00221, (Mouse) O54910
Entrez Gene ID: (Human) 4794, (Mouse) 18037, (Rat) 316241
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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