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Product Details
PA5-103495
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:1,000-1:3,000 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
A synthesized peptide derived from human NFKBIL1(Accession Q9UBC1), corresponding to amino acid residues P119-G145. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1 mg/mL |
Purification |
Affinity chromatography |
Storage buffer |
PBS, pH 7.4, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
RRID |
AB_2852831 |
Target Information
NF-kappa-B inhibitor-like protein 1 (NFKBIL1), also named Ikb like and IkbL1, is a 381 amino acid member of the inhibitor of NF-kappaB (IkappaB) family of proteins. NFKBIL1 contains two ANK repeats and is expressed in the rheumatoid synovial lining and sub-lining layers and co-localized in CD68+ and CD3+, but not Factor VIII+ cells. It is reported that defects in NFKBIL1 expression causes of susceptibility to rheumatoid arthritis (RA), which is a systemic inflammatory disease with autoimmune features and affects the joints. Rheumatoid arthritis (RA) is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DADB-70P7.2; I-kappa-B-like protein; ikappaBL; Inhibitor of kappa B-like protein; NF-kappa-B inhibitor-like protein 1; Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
Gene Aliases: Def-7; IKBL; LST1; NFKBIL; NFKBIL1
UniProt ID: (Human) Q9UBC1, (Mouse) O88995, (Rat) Q8R2H1
Entrez Gene ID: (Human) 4795, (Mouse) 18038, (Rat) 361794
Molecular Function:
protein-binding activity modulator
I-kappaB kinase/NF-kappaB signaling
negative regulation of lipopolysaccharide-mediated signaling pathway
negative regulation of NF-kappaB transcription factor activity
negative regulation of tumor necrosis factor production
negative regulation of toll-like receptor signaling pathway
cytoplasmic sequestering of transcription factor
cellular response to lipopolysaccharide
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